Weight and Health – Pathophysiology | NEJM

 

This text discusses the challenges of weight control, the role of genetics and environment, and the health implications of obesity.

Highlights

🏋️ Weight control is not solely a matter of willpower; physical factors play a significant role.

🧠 Our body defends a certain fat mass set point, making weight loss difficult.

🍔 The obesogenic environment contributes to disregulating this system.

🧬 Genetics plays a substantial role in obesity, but it's not purely genetic.

⚖️ The environment physically affects weight-regulating pathways.

🩺 Excess fat cell hormones contribute to obesity-related diseases.

💉 Medical therapies and bariatric surgery are underutilized for obesity treatment.